DOI: https://doi.org/10.32776/revbiomed.v35i2.1186

Aspartato aminotransferasa salival biomolécula diagnóstica de periodontitis como puente de interacción multidisciplinaria

Irma Zamora-Ginez, Blanca Guadalupe Baez-Duarte, Eduardo Monjaraz, Guillermo Franco-Romero, Dan J. Peralta-Prado, Abigail Briones-Montiel

Resumen

Introducción: Es necesaria una adecuada interacción multidisciplinaria entre médicos y profesionales de la salud bucodental para disminuir las repercusiones de la enfermedad periodontal.

Objetivo: Determinar si aspartato aminotransferasa salival (AST) es mejor biomolécula diagnóstica de periodontitis comparada con AST sérica e Interleucina- 6 (IL-6) y factor de necrosis tumoral-alfa (TNF-α) salivales y séricas.

Material y Método: Estudio de metodología mixta, compuesta por dos subestudios, el primero, experimental, comparativo, transversal, retrospectivo para determinar la capacidad diagnóstica de AST, IL-6 y TNF-α salivales y séricas en sujetos sin diagnóstico de periodontitis que acuden al servicio de medicina general y el segundo, experimental, comparativo, longitudinal, para confirmar la capacidad diagnóstica de AST salival (ASTsa), antes y después de tratamiento periodontal en sujetos que acuden al servicio de salud bucodental. El diagnóstico de periodontitis se determinó mediante el índice de Extensión y Severidad (IES).

Resultados: Solo los niveles de ASTsa fueron diferentes entre sujetos sin y con periodontitis (p < 0,0005), los cuales correlacionaron con la extensión (r = 0.410, p < 0.0005) y severidad (r = 0.428, p < 0.0005) del IES, y presentaron un punto de corte de 16.0 UI / mL con alta capacidad discriminativa (Área bajo la curva = 0.936, IC 95 %, 0.864 - 1,000; p < 0,001). Además, posterior a tratamiento periodontal los niveles de ASTsa disminuyeron (116.9 ± 76.2. U/L vs 58.8 ± 47.0 U/L, p < 0.001).

Conclusión: ASTsa es la mejor biomolécula diagnóstica de periodontitis que podría utilizarse como puente de interacción multidisciplinaria.

Palabras claves: Aspartato aminotransferasa salival, periodontitis, interacción multidisciplinaria

Título corto: AST salival y diagnóstico de periodontitis.

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Referencias

|1. Bains VK, Chandra H, Jamaluddin K, Bains R. Awareness among health care professionals regarding interrelationship between diabetes mellitus and periodontal diseases: A step towards interprofessional collaborative practice. Asian J Oral Heal Allied Sci. 2020 Dic; 10(10): 10. https://doi.org/10.25259/AJOHAS_16_2020

Siddiqi A, Zafar S, Sharma A, Quaranta A. Diabetes mellitus and periodontal disease: The call for interprofessional education and interprofessional collaborative care - A systematic review of the literature. J Interprof Care. 2022 Ene; 36(1): 93–101. https://doi.org/10.1080/13561820.2020.1825354

Variath PT, Biniraj K, Rishi E, Tony PP, Priya J, Divyasree K. The effect of periodontal therapy on glycaemic level in patients with controlled type 2 diabetes mellitus on sulfonylurea oral hypoglycaemic agents. Int J Appl Dent Sci. 2022 Ene; 8(1): 466–70. https://doi.org/10.22271/oral.2022.v8.i1g.1464

Herrera D, Sanz M, Shapira L, Brotons C, Chapple I, Frese T, et al. Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization. J Clin Periodontol. 2023 Ene; 50(6): 819–41. https://doi.org//10.1111/jcpe.13807

Sadek K, El Moshy S, Radwan I, Rady D, Abbass M, El-Rashidy A, et al. Molecular basis beyond Interrelated bone resorption/regeneration in periodontal diseases: A Concise Review. Int J Mol SciMolecular Sci. 2023 Feb; 24(5): 4599. https://doi.org//10.3390/ijms24054599

Giraldo A, Roldan N, Duque A, Navarro JC. Índice de extensión y severidad (ESI) como parámetro para describir la respuesta a la terapia clínica en el manejo de la enfermedad periodontal. CES Odontol. 2006 Dic; 19(2): 17–24. https://pesquisa.bvsalud.org/portal/resource/pt/lil-454869

Dhingra K, Vandana KL. Indices for measuring periodontitis: A literature review. Int Dent J. 2011 Abr; 61: 76–84. https://doi.org//10.1111/j.1875-595X.2011.00018.x

Manandhar S, Prasanth T, Satisha TS, Kumar P. Salivary diagnostic biomarker for periodontal disease - A review. J Dent Spec. 2021 Oct; 9(1): 7–12. https://doi.org//10.18231/j.jds.2021.003

Alsaykhan K, Khan NS, Aljumah MI, Albughaylil AS. comparative evaluation of salivary enzyme in patients with gingivitis and periodontitis: A clinical-biochemical study. Cureus. 2022 Ene; 14(1): e20991. https://doi.org//10.7759/cureus.20991

AlMoharib HS, AlMubarak A, AlRowis R, Geevarghese A, Preethanath RS, Anil S. Oral fluid based biomarkers in periodontal disease: part 1. Saliva. JIOH. 2014 Jul; 6(4):95–103. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148585/

Todorovic T, Dozic I, Vicente-Barrero M, Ljuskovic B, Pejovic J, Marjanovic M, et al. Salivary enzymes and periodontal disease. Medi oral, patol oral cir bucal. 2006 Mar; 11(2): E115-9. http://www.ncbi.nlm.nih.gov/pubmed/16505786

Shinde H, Gaddale R, Ilangovan K. Use of saliva aspartate aminotransferase in diagnosing periodontal disease: A clinical and biochemical study. J Dr NTR Univ Heal Sci. 2022 Ago; 11(2): 107. https://doi.org//10.4103/JDRNTRUHS.JDRNTRUHS_90_20

Figueredo CM, Lira-Junior R, Love RM. T and B cells in periodontal disease: New functions in a complex scenario. Int J Mol Sci. 2019 Ago; 20(16): 1–13. https://doi.org//10.3390/ijms20163949

Sarasati A, Jonarta AL. Potential targets of phytochemical immunomodulatory therapy in periodontitis immunopathogenesis: A narrative review. Saudi Dent J. 2023 Dic; 35(8): 920–8. https://doi.org//10.1016/j.sdentj.2023.08.005

Gümüş P, Nizam N, Lappin DF, Buduneli N. saliva and serum levels of B‐cell activating factors and Tumor Necrosis Factor‐α in patients with periodontitis. J Periodontol. 2014 Feb; 85(2): 270–80. http://www.joponline.org/doi/10.1902/jop.2013.130117

Kibune R, Muraoka K, Morishita M, Ariyoshi W, Awano S. Relationship between dynamics of TNF-α and Its soluble receptors in saliva and periodontal health state. Dent J. 2022 Feb; 10(2): 25. https://doi.org//10.3390/dj10020025

Bagan L, Sáez GT, Tormos MC, Labaig-Rueda C, Murillo-Cortes J, Bagan J V. Salivary and serum interleukin-6 levels in proliferative verrucous leukoplakia. Clin Oral Invest [Internet]. 2016 May; 20(4): 737–43. https://doi.org//10.1007/s00784-015-1551-z

Carrillo De Albornoz Sainz A, García Kass A, Bascones Martínez A. Papel de la IL-6 TNF-α en la enfermedad periodontal. Av Periodoncia. 2006 Ago; 18(2): 83–9. http://scielo.isciii.es/pdf/peri/v18n2/original2.pdf

Ridha HS, Kadri ZHM. Assessment of liver enzymes in saliva and serum of Iraqi patients with chronic periodontitis disease. J Biotechnol Res Cent . 2020 Ene; 14(1): 20–4. https://doi.org//10.24126/jobrc.2020.14.1.584

MedlinePlus [Internet]. AST Test [Internet]. Bethesda (MD): National Library of Medicine (US). 2022 [citado 2023 Ago 16]. https://medlineplus.gov/lab-tests/ast-test/#:~:text=An%20AST%20blood%20test%20is,help%20diagnose%20other%20health%20conditions.

Brailo V, Vucicevic-Boras V, Lukac J, Biocina-Lukenda D, Alajbeg-Zilic I, Milenovic A, et al. Salivary and serum interleukin 1 beta, interleukin 6 and tumor necrosis factor alpha in patients with leukoplakia and oral cancer. Medi Oral Patol Oral Cir Bucal. 2012 Ene; 17(1): e10–5. https://doi.org//10.4317/medoral.17323

Costa PP, Trevisan GL, Macedo GO, Palioto DB, Souza SLS, Grisi MFM, et al. salivary interleukin‐6, matrix metalloproteinase‐8, and osteoprotegerin in patients with periodontitis and diabetes. J Periodontol. 2010 Mar; 81(3): 384–91. http://www.joponline.org/doi/10.1902/jop.2009.090510

Jung Y, Kim J-H, Shin A-R, Song K-B, Amano A, Choi Y-H. association of adiposity with periodontitis and metabolic syndrome: from the third national health and nutrition examination survey of United States. Int J Env Res Public Heal. 2023 Ene; 20(3): 2533. https://doi.org//10.3390/ijerph20032533

Carlos JP, Wolfe MD, Kingman A. The extent and severity index: a simple method for use in epidemiologic studies of periodontal disease. J Clini Periodontol. 1986 May; 13(5): 500–5. http://doi.wiley.com/10.1111/j.1600-051X.1986.tb01497.x

Wiebe CB, Putnins EE. The periodontal disease classification system of the American Academy of periodontology-an update. J Can Dent Assoc. 2000 Dic; 66(11): 594–7. https://www.cda-adc.ca/jcda/vol-66/issue-11/594.pdf

Cerda J, Cifuentes L. Uso de curvas ROC en investigación clínica. Aspectos teórico-prácticos. Rev Chil Infectol. 2012 Abr; 29(2): 138–41.

https://doi.org//10.4067/S0716-10182012000200003

Marouf N, Cai W, Said KN, Daas H, Diab H, Chinta VR, et al. Association between periodontitis and severity of COVID‐19 infection: A case–control study. J Clin Periodontol. 2021 Abr; 48(4): 483–91. https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13435

Risteska N, Poposki B, Ivanovski K, Dirjanska K, Ristoska S, Saveski M. Diagnostic and prognostic markers of periodontal disease. PRILOZI. 2021 Dic; 42(3): 89–95. https://doi.org//10.2478/prilozi-2021-0039

Luke R, Khan SN, Iqbal PS, Soman RR, Chakkarayan J, Krishnan V. Estimation of specific salivary enzymatic biomarkers in individuals with gingivitis and chronic: A Clinical and Biochemical Study. J Int Oral Heal. 2015 Sep; 7(9): 54–7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589720/

Kudva P, Saini N, Kudva H, Saini V. To estimate salivary aspartate aminotransferase levels in chronic gingivitis and chronic periodontitis patients prior to and following non-surgical periodontal therapy: A clinico-biochemical study. J Indian Soc Periodontol [Internet]. 2014;18(1):53. https://pubmed.ncbi.nlm.nih.gov/24744545/

Caliaperoumal SK, Gnanasekaran H, Kaliamoorthy S. Comparison of lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in saliva of normal, gingivitis and periodontitis patients. Int J Dent Oral Sci. 2021 Nov; 8(88): 5164–7. https://doi.org//10.19070/2377-8075-210001037

Abdel Kader K, Elhabbak S, Assadawy M. Evaluation of some salivary enzymes as a diagnostic biomarker for progression of periodontal disease. Al-Azhar J Dent Sci. 2021 Abr; 24(2): 175–86. https://doi.org//10.21608/ajdsm.2020.34246.1076

Nomura Y, Tamaki Y, Tanaka T, Arakawa H, Tsurumoto A, Kirimura K, et al. Screening of periodontitis with salivary enzyme tests. J Oral Sci. 2006 Dic; 48(4): 177–83. https://doi.org//10.2334/josnusd.48.177

Fujii T, Aoyama N, Kida S, Taniguchi K, Yata T, Minabe M, et al. Associations between periodontal status and liver function in the japanese population: A cross-sectional study. J Clin Med. 2023 Jul; 12(14): 4759. https://doi.org//10.3390/jcm12144759

Huang Y, Zhang Q, Guo Z, Deng G, Chen R, Zheng Y. Potential noninvasive biomarkers for the malignant transformation of oral leukoplakia: A systematic review and meta‐analysis. Cancer Med. 2023 Jul; 12(13): 14718–30. https://onlinelibrary.wiley.com/doi/10.1002/cam4.6095

Chen D, Zhong L, Li Y, He R, Ding C, Chen X, et al. Changes in serum inflammatory factor interleukin-6 levels and pathology of carotid vessel walls of rats with chronic periodontitis and diabetes mellitus after the periodontal intervention. Saudi J Biol Sci. 2020 Jun; 27(6): 1679–84. https://doi.org//10.1016/j.sjbs.2020.04.029

DOI: https://doi.org/10.32776/revbiomed.v35i2.1186

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